منابع مشابه
Maternal control of early mouse development.
The hiatus between oocyte and embryonic gene transcription dictates a role for stored maternal factors in early mammalian development. Encoded by maternal-effect genes, these factors accumulate during oogenesis and enable the activation of the embryonic genome, the subsequent cleavage stages of embryogenesis and the initial establishment of embryonic cell lineages. Recent studies in mice have y...
متن کاملMaternal DNA Methylation Regulates Early Trophoblast Development
Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the extraembryonic lineage that gives rise to the placenta. We dissected the role of DNA methylation in trophoblast development by performing mRNA and DNA methylation profiling of Dnmt3a/3b mutants. We find that oocyte-derived methylation plays a ma...
متن کاملThe Predictors for Maternal Self-efficacy in Early Parenthood
Background & aim: Many parents do not believe in their ability to fulfill their parental responsibilities. Parental self-efficacy is crucial to parents’ sense of well-being and is considered a predictor for quality of life. However, evidence is scarce on the factors that influence parents’ perception of efficacy. Therefore, this study aimed to investigate the predictors for parental self-effica...
متن کاملMaternal BCAS2 protects genomic integrity in mouse early embryonic development.
Mammalian early embryos maintain accurate genome integrity for proper development within a programmed timeline despite constant assaults on their DNA by replication, DNA demethylation and genetic defects transmitted from germ cells. However, how genome integrity is safeguarded during mammalian early embryonic development remains unclear. BCAS2 (breast carcinoma amplified sequence 2), a core com...
متن کاملEffects of maternal diabetes on visual evoked potentials and early psychomotor development of the offspring.
P lanning and intensive treatment of diabetes in pregnancy has resulted in dramatic improvements in outcomes in terms of congenital malformations or perinatal morbidity (1), but it is still not clear to what extent maternal diabetes affects cognitive development of newborns. In infants of diabetic mothers (IDMs), significant relations have been reported between poor maternal metabolic regulatio...
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ژورنال
عنوان ژورنال: Nature
سال: 1978
ISSN: 0028-0836,1476-4687
DOI: 10.1038/276017a0